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KMID : 0353320140380020083
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Oral Biology Research
2014 Volume.38 No. 2 p.83 ~ p.91
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Experimental study on healing procedure after combined grafting of recombinant human bone morphogenetic protein-2 and anorganic bovine bone
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Ahn Gyo-Jin
Park Ju-Cheol
Kim Young-Kyun
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Abstract
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Purpose: The purpose of this study was to evaluate a bone healing procedure using anorganic bovine bone and recombinant human bone morphogenetic protein-2 (rhBMP-2).
Materials and Methods: Anorganic bovine bone (Bio-Oss®; Geistlich Pharma AG, Wolhausen, Switzerland) was grafted at two preformed alveolar bone defects in beagle dogs. One was filled only with Bio-Oss® while the other was filled with Bio-Oss® mixed with rhBMP-2. Both animals were sacrificed at 2, 4, and 8 weeks after the experiment. Block specimens, including grafted bone and surrounding bone, were harvested and histological healing procedure evaluated.
Results: Increased strength and radiopacity were observed in both groups in a time-dependent manner. However, when using rhBMP-2 together, more new and matured bone was formed histologically.
Conclusion: In this study, we showed that rhBMP-2 can promote bone formation effectively, and anorganic bovine bone can be used as a scaffold.
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KEYWORD
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Bio-Oss, Recombinant human bone morphogenetic protein-2, Scaffold
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